Is DMT an Effective Antidepressant?

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Many anecdotal reports suggest that DMT can have antidepressant effects, both in terms of microdosing the substance and by means of larger doses, which result in mystical experiences. While we have seen a flourishing of research into the antidepressant potential of psilocybin (the active ingredient in ‘magic mushrooms’), little research has been carried out into DMT’s capacity to lift people out of depression. However, some interesting studies and conclusions do help to strengthen the idea that DMT could be used in this therapeutic context.

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Originally published at on February 17, 2020.

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